1 Biochemistry & Medicine 1
Victor W. Rodwell, PhD &Robert K. Murray, MD, PhD
2 Water & pH 6
Peter J. Kennelly, PhD &Victor W. Rodwell, PhD
3 Amino Acids & Peptides15
Peter J. Kennelly, PhD &Victor W. Rodwell, PhD
4 Proteins: Determination ofPrimary
Structure 25
Peter J. Kennelly, PhD &Victor W. Rodwell, PhD
5 Proteins: Higher Orders ofStructure 36
Peter J. Kennelly, PhD & Victor W. Rodwell, PhD
6 Proteins: Myoglobin & Hemoglobin 51
Peter J. Kennelly, PhD &Victor W. Rodwell, PhD
7 Enzymes: Mechanism ofAction 60
Peter J. Kennelly, PhD &Victor W. Rodwell, PhD
8 Enzymes: Kinetics 73
Peter J. Kennelly, PhD &Victor W. Rodwell, PhD
9 Enzymes: Regulation ofActivities 87
Peter J. Kennelly, PhD & Victor W. Rodwell, PhD
10 Bioinformatics & Computational
Biology 97
Peter J. Kennelly, PhD & Victor W. Rodwell, PhD
11 Bioenergetics: The Role ofATP 113
Kathleen M. Botham, PhD, DSc& Peter A. Mayes, PhD, DSc
12 Biologic Oxidation 119
Kathleen M. Botham, PhD, DSc& Peter A. Mayes, PhD, DSc
13 The Respiratory Chain &Oxidative
Phosphorylation 126
Kathleen M. Botham, PhD, DSc & Peter A. Mayes, PhD,DSc
14 Overview of Metabolism& the Provision
of Metabolic Fuels 139
David A. Bender, PhD &Peter A. Mayes, PhD, DSc
15 Carbohydrates ofPhysiological
Significance 152
David A. Bender, PhD &Peter A. Mayes, PhD, DSc
16 The Citric Acid Cycle: TheCentral Pathway
of Carbohydrate, Lipid & Amino Acid
Metabolism 161
David A. Bender, PhD & Peter A. Mayes, PhD, DSc
17 Glycolysis & theOxidation of Pyruvate 168
David A. Bender, PhD &Peter A. Mayes, PhD, DSc
18 Metabolism of Glycogen 176
David A. Bender, PhD &Peter A. Mayes, PhD, DSc
19 Gluconeogenesis & theControl of Blood
Glucose 185
David A. Bender, PhD &Peter A. Mayes, PhD, DSc
20 The Pentose PhosphatePathway & Other
Pathways of Hexose Metabolism 196
David A. Bender, PhD & Peter A. Mayes, PhD, DSc
21 Lipids of PhysiologicSignificance 211
Kathleen M. Botham, PhD, DSc& Peter A. Mayes, PhD, DSc
22 Oxidation of Fatty Acids:Ketogenesis 223
Kathleen M. Botham, PhD, DSc& Peter A. Mayes, PhD, DSc
23 Biosynthesis of Fatty
Acids & Eicosanoids 232
Kathleen M. Botham, PhD, DSc& Peter A. Mayes, PhD, DSc
24 Metabolism of Acylglycerols
& Sphingolipids 245
Kathleen M. Botham, PhD, DSc& Peter A. Mayes, PhD, DSc
25 Lipid Transport &Storage 253
Kathleen M. Botham, PhD, DSc& Peter A. Mayes, PhD, DSc
26 Cholesterol Synthesis,Transport,
& Excretion 266
Kathleen M. Botham, PhD, DSc & Peter A. Mayes, PhD,DSc
27 Biosynthesis of theNutritionally
Nonessential Amino Acids 281
Victor W. Rodwell, PhD
28 Catabolism of Proteins& of Amino Acid
Nitrogen 287
Victor W. Rodwell, PhD
29 Catabolism of the CarbonSkeletons of
Amino Acids 297
Victor W. Rodwell, PhD
30 Conversion of Amino Acidsto Specialized
Products 313
Victor W. Rodwell, PhD
31 Porphyrins & BilePigments 323
Victor W. Rodwell, PhD & Robert K. Murray, MD, PhD
32 Nucleotides 339
Victor W. Rodwell, PhD
33 Metabolism of Purine &Pyrimidine
Nucleotides 347
Victor W. Rodwell, PhD
34 Nucleic Acid Structure& Function 359
P. Anthony Weil, PhD
35 DNA Organization,Replication,
& Repair 370
P. Anthony Weil, PhD
36 RNA Synthesis, Processing,
& Modification 394
P. Anthony Weil, PhD
37 Protein Synthesis & theGenetic Code 413
P. Anthony Weil, PhD
38 Regulation of GeneExpression 428
P. Anthony Weil, PhD
39 Molecular Genetics,Recombinant DNA,
& Genomic Technology 451
P. Anthony Weil, PhD
40 Membranes: Structure
& Function 477
Robert K. Murray, MD, PhD& P. Anthony Weil, PhD
41 The Diversity of theEndocrine
System 498
P. Anthony Weil, PhD
42 Hormone Action & Signal
Transduction 518
P. Anthony Weil, PhD
43 Nutrition, Digestion,
& Absorption 537
David A. Bender, PhD &Peter A. Mayes , PhD, DSc
44 Micronutrients: Vitamins
& Minerals 546
David A. Bender, PhD
45 Free Radicals &Antioxidant
Nutrients 564
David A. Bender, PhD
46 Glycoproteins 569
David A. Bender, PhD &Robert K. Murray, MD, PhD
47 Metabolism of Xenobiotics583
David A. Bender, PhD &Robert K. Murray, MD, PhD
48 Clinical Biochemistry 589
David A. Bender, PhD, JoeVarghese, MBBS, MD,
Molly Jacob, MBBS, MD, PhD,& Robert K.
Murray, MD, PhD
49 Intracellular Traffic &Sorting of Proteins 607
Kathleen M. Botham , PhD, DSc& Robert K. Murray, MD, PhD
50 The Extracellular Matrix627
Kathleen M. Botham, PhD, DSc& Robert K. Murray, MD, PhD
51 Muscle & theCytoskeleton 647
Peter J. Kennelly, PhD &Robert K. Murray, MD, PhD
52 Plasma Proteins & Immunoglobulins668
Peter J. Kennelly, PhD, RobertK. Murray, MD, PhD, Molly
Jacob, MBBS, MD, PhD & JoeVarghese, MBBS, MD
53 Red Blood Cells 689
Peter J. Kennelly, PhD &Robert K. Murray, MD, PhD
54 White Blood Cells 700
Peter J. Kennelly, PhD & Robert K. Murray, MD, PhD
55 Hemostasis & Thrombosis711
Peter L. Gross, MD, MSc,FRCP(C), Robert K. Murray, MD, PhD,
P. Anthony Weil, PhD, &Margaret L. Rand, PhD
56 Cancer: An Overview 722
Molly Jacob, MBBS, MD, PhD,Joe Varghese, MBBS, MD,
Robert K. Murray, MD, PhD& P. Anthony Weil, PhD
57 Biochemical Case Histories746
David A. Bender, PhD
58 The Biochemistry of Aging755
Peter J. Kennelly, PhD
The Answer Bank 771
Index 777R61h