1. 1. The 7th edition has two new chapters - "Hematopoiesis" and "Neoplastic Hematology", and additional sections, such as one on "Genomics and Genetics in Hematology."
   2. New and updated content: The content throughout the book has been revised and updated, reflecting the latest research and advancements in the field of hematology. The authors have incorporated new information on topics like gene editing, CAR-T cell therapy, and molecular diagnostics.
   3. Enhanced online resources: The 7th edition comes with an online resource center that includes additional content such as animations, self-assessment questions, and case studies.
   4. Improved layout and design: The book's layout and design have been improved to make it more readable and user-friendly, with new tables, illustrations, and images.
   5. Advances in the understanding of the genetic basis of hematological disorders, including the discovery of new driver mutations in acute myeloid leukemia (AML) and myeloproliferative neoplasms (MPNs).
   6. Updates to the classification and management of hematological disorders, including changes to the World Health Organization (WHO) classification of myeloid neoplasms and acute lymphoblastic leukemia (ALL).
   7. Advances in the treatment of hematological disorders, including the development of new targeted therapies for chronic lymphocytic leukemia (CLL) and multiple myeloma.
   8. Expanded coverage of the role of the bone marrow microenvironment in the pathogenesis of hematological disorders.
   9. Updates to the chapters on hemostasis and thrombosis, including new information on the genetic basis of inherited bleeding disorders and the role of platelets in thrombosis.
   10. A new chapter on the use of laboratory tests in the diagnosis and management of hematological disorders, including advances in molecular diagnostics and the use of flow cytometry in the diagnosis of lymphoid neoplasms.
   11. Provides up-to-date knowledge of the pathogenesis, clinical and laboratory features and treatment of all blood disorders
   12. Added detailed information on the new genetics of leukaemia and lymphoma
   13. Includes a new chapter on thrombosis, focusing on the new oral anticoagulants
   14. Is beautifully presented, with over 300 colour illustrations
   15. Comprehensively covers both theory and treatment regimes.

1. "Hoffbrand's Essentials of Haematology" is a comprehensive resource that focuses on the study of blood and blood disorders. Written by A. Victor Hoffbrand, Paul A.H. Moss, and Pettit John E. Bain, the seventh edition builds upon the success of previous editions and provides updated information in the field of hematology.

   The book covers various aspects of hematology, starting with an introduction to the structure and function of blood cells and their production within the bone marrow. It then delves into the physiology and disorders of red blood cells, white blood cells, and platelets, discussing their normal functions and the diseases that can affect them.

   The book extensively covers different types of hematological disorders, including anemias, leukemias, lymphomas, and myeloproliferative disorders. It explains the pathogenesis, clinical features, diagnosis, and management of these conditions. The text also explores the principles and techniques used in laboratory hematology, including blood cell morphology, blood transfusion, and molecular diagnostics.

   The book is divided into 16 chapters, which cover the following topics:

   Haemopoiesis

   Erythropoiesis and general aspects of anaemia

   Hypochromic anaemias

   Iron overload

   Megaloblastic anaemias and other macrocytic anaemias

   Haemolytic anaemias

   Genetic disorders of haemoglobin

   The white cells 1: granulocytes, monocytes and their benign disorders

   The white cells 2: lymphocytes and their benign disorders

   The spleen

   The aetiology and genetics of haematological malignancies

   Management of haematological malignancy

   Acute myeloid leukaemia

   Chronic myeloid leukaemia

   Myeloproliferative disease

   Myelodysplasia

1. Here are some reviews of Hoffbrand's Essential Haematology, 7th Edition:

   • "A must-have for all haematology trainees." - British Journal of Haematology
   • "An excellent resource for students and clinicians alike." - Journal of Clinical Pathology
   • "A comprehensive and up-to-date textbook of haematology." - The Lancet

   Here are some specific comments from reviewers:

   • "The book is well-written and easy to read, even for those with no prior knowledge of haematology."
   • "The illustrations are clear and helpful."
   • "The book is comprehensive and covers all aspects of haematology."
   • "The book is up-to-date with the latest research."
   • "The book is an excellent resource for students, trainees, and clinicians alike."

   Overall, Hoffbrand's Essential Haematology, 7th Edition is a well-written, comprehensive, and up-to-date textbook of haematology. It is an essential resource for students, trainees, and clinicians alike.

   Here are some additional thoughts on the book:

   • The book is organized in a logical way, making it easy to find the information you need.
   • The book is packed with information, but it is not overwhelming.
   • The book is well-referenced, so you can easily find additional information on any topic.
   • The book is a valuable resource for anyone who wants to learn more about blood disorders.

1. Short Cases in Surgery, 6th edition is, in its present form, a new edition and not merely a reprint. The purpose of this new edition remains the same as those of the previous editions. The entire text has been thoroughly revised and updated. Two new chapters, soft tissue sarcoma, and intestinal stomas have been included. The aim of this book is to help the students, who are preparing for qualifying examinations, readily grasping the problems of surgery-the problems they have to tackle in their examinations as well as in the wider world outside the examination halls.

   It is really gratifying for an author of a book to find it running through many editions. It indicates that the book has proved to be satisfying the needs of the students (and. as they say. also of the teachers) in the institutions of medical learning.

1. 1. Comprehensive and authoritative coverage of hematology topics, including the basics, red and white blood cell disorders, hemostasis and thrombosis, and transfusion medicine and hematopoietic stem cell transplantation.
   2. Updated material that reflects the latest research and advances in the field, including two new chapters on genomics and genetics in hematology.
   3. Self-assessment questions at the end of each chapter to help readers test their understanding of the material.
   4. Case studies to illustrate how the concepts learned in the book apply to real-world situations.
   5. Interactive animations to help readers visualize complex concepts and processes in hematology.
   6. Access to the ExpertConsult eBook version, which includes additional online-only content
   7. Emphasis on the clinical relevance of the material, with numerous case studies, clinical examples, and illustrations to aid understanding.
   8. Detailed coverage of the diagnosis and management of a wide range of hematological disorders, including anemia, hemoglobinopathies, bleeding and clotting disorders, and various types of leukemia and lymphoma.
   9. Updates and additions reflecting the latest advances in research and clinical practice, including new information on the genetic basis of hematological disorders, changes to the classification and management of hematological disorders, and expanded coverage of the role of the bone marrow microenvironment in the pathogenesis of hematological disorders.
   10. New chapters on the use of laboratory tests in the diagnosis and management of hematological disorders, and on the role of the spleen in hematological disorders.
   11. Authored by two leading experts in the field, A. Victor Hoffbrand and Paul A. H. Moss.
   12. Provides up-to-date knowledge of the pathogenesis, clinical and laboratory features, and treatment of all blood disorders
   13. A classic and definitive haematology textbook of choice for medical students.
   14. The 7th edition has been updated with the latest knowledge and research in the field of haematology Authored by Victor Hoffbrand and Paul A. H. Moss, published by Wiley Blackwell in 2016, and has 784 pages.
   15. The book won the British Medical Association Book Award for Student Textbook of the Year in 2016.
   16. The book is a valuable resource for medical students and professionals in the field of haematology
   17. The 7th edition is available in paperback format.
   18. The companion resources site for the 8th edition of Hoffbrand's Essential Haematology is available online

The 7th edition of "Hoffbrand's Essential Haematology" is a comprehensive and authoritative textbook on the fundamental principles of hematology. The book covers five main sections, including the basics of hematology, red blood cell disorders, white blood cell, and lymphoid disorders, hemostasis and thrombosis, transfusion medicine, and hematopoietic stem cell transplantation.

This new edition is extensively revised and updated to reflect the latest research and advancements in the field, including two new chapters and additional sections covering genomic and genetic advances in hematology. The book also includes self-assessment questions, animations, and case studies to help students deepen their understanding of the material.

Hoffbrand's Essential Hematology, 7th edition is a valuable resource for students, trainees, and practitioners in the field of hematology, providing a comprehensive and clinically relevant overview of the subject.

Hoffbrand's Essential Hematology, 7th edition provides a comprehensive overview of the field of hematology, covering both basic science and clinical aspects. The book is divided into five sections, starting with an introduction to the blood and hematopoietic system, followed by sections on red blood cell disorders, white blood cell disorders, hemostasis and thrombosis, and finally, neoplastic disorders of the blood and bone marrow.

The seventh edition includes several updates and additions compared to the sixth edition, reflecting the latest advances in research and clinical practice. These updates include advances in the understanding of the genetic basis of hematological disorders, updates to the classification and management of hematological disorders, and expanded coverage of the role of the bone marrow microenvironment in the pathogenesis of hematological disorders.

The book also includes new chapters on the use of laboratory tests in the diagnosis and management of hematological disorders, and on the role of the spleen in hematological disorders. Throughout the book, there is an emphasis on the clinical relevance of the material, with numerous case studies, clinical examples, and illustrations to aid understanding.

Overall, Hoffbrand's Essential Hematology, 7th edition is a valuable resource for students, trainees, and practitioners in the field of hematology, providing a comprehensive and up-to-date overview of the subject.

There have been remarkable advances in the understanding of the pathogenesis of diseases of the blood and lymphatic system and in the treatment of these diseases since the 6th Edition of Essential Haematology was published in 2011. This new knowledge is due largely to the application of next-generation sequencing of DNA which has enabled the detection of the genetic mutations, inherited or acquired, that underlie these diseases. As an example, sequencing has revealed the CALR mutation underlying a substantial proportion of patients with myeloproliferative diseases and the MYD88 mutation present in almost all cases of Waldenstrom’s macroglobulinaemia. Multiple ‘driver’ gene mutations affecting signalling pathways and epigenetic reactions involved in cell proliferation and survival have been discovered which underlie myelodysplasia, acute myeloid and lymphoblastic leukaemias, chronic lymphocytic leukaemia and lymphomas. The complexity of the molecular changes underlying malignant diseases and the relevance of this to their sensitivity or resistance to therapy is becoming apparent.

This new knowledge has been accompanied by spectacular improvements in therapy. Inhibition of the B cell receptor signalling pathway has transformed the life expectancy in many patients with resistant chronic lymphocytic leukaemia and some of the B cell lymphomas resistant to other therapy. JAK2 inhibitors are improving the quality of life and survival in primary myelofibrosis. Survival in myeloma is improving remarkably with new proteasome inhibitory and immunomodulatory drugs. Life expectancy has also improved for patients with diseases such as thalassaemia major receiving multiple transfusions with the worldwide introduction of orally active iron chelating agents. New anticoagulants which directly inhibit at a single point in the coagulation cascade and rarely need monitoring are now used commonly in preference to warfarin for the treatment and prevention of arterial and venous thrombosis.

These advances in knowledge have been incorporated as new text, diagrams and tables for this seventh edition. New multiple-choice questions have been added to the website and short summary boxes are included at the end of each chapter.

We thank Dr Trevor Baglin for his helpful suggestions for the coagulation section of the book. We wish to thank our publishers Wiley‐Blackwell and the staff who have helped us with the production of this 7^th Edition. We also thank Jane Fallows for once more producing clear, expertly drawn scientific diagrams. We hope it will be widely used both by undergraduates and by postgraduates in medicine and related sciences wishing to gain a grounding in one of the most exciting and advanced fields of medicine.

Victor Hoffbrand

Paul Moss