1. Robbins and Cotran. Where an effective understanding of disease begins. A current and accurate understanding of pathophysiology is integral to effective practice in every specialty. No source delivers that understanding better than the Robbins and Cotran family! Robbins Basic Pathology, Robbins Essential Pathology, and their many companion resources provide a clear, up-to-date explanation of disease mechanisms you need to succeed.

   New to this edition: Neoplasia, infectious diseases, diseases of white blood cells, lymph nodes, spleen and thymus, red blood cell and bleeding disorders, the lung, head & neck, the gastrointestinal tract, liver and gallbladder, the kidney, the breast, the endocrine system, the skin, the central nervous system, the eye, the transfusion medicine.

1. Offering rapid, portable access to key concepts and principles of pathology from Robbins and Cotran Pathologic Basis of Disease, 10th Edition, this up-to-date book and makes it easy to locate essential information on the go. The condensed, at-a-glance format, organized to parallel the parent text, is ideal for quick review-anytime, anywhere.

1. Readable and highly illustrated, Robbins and Cotran Pathologic Basis of Disease, 10th Edition presents an in-depth, state-of-the-art overview of human diseases and their cellular and molecular basis. This best-selling text delivers the latest, most essential pathology knowledge in a readable, interesting manner, ensuring optimal understanding of the latest basic science and clinical content. More than 1,000 high-quality photographs and full-color illustrations highlight new information in molecular biology, disease classifications, new drugs and drug therapies, and much more. This superb learning package also includes an enhanced eBook with a full complement of ancillary content on Student Consult.

1. • Provides uniquely authoritative and readable coverage, ideal for USMLE or specialty board preparation, as well as for coursework.
   • Covers the hot topics you need to know about, including novel therapies for hepatitis C, classification of lymphomas, unfolded protein response, non-apoptotic pathways of cell death, coronavirus infections, liquid biopsy for cancer detection, regulation of iron absorption, clonal hematopoiesis and atherosclerosis, thrombotic microangiopathies, heparin-induced thrombocytopenias, inflammatory myopathies, genetic tools for treatment of cystic fibrosis, and many more.
   • Uses an outstanding full-color, user-friendly design to simplify your study and quickly direct you to the information you need to know, with learning features such as boldface overviews at the beginning of each section, key concepts boxes, suggested readings, schematic diagrams that illustrate complex concepts, and new gross and microscopic figures for clarity of morphology.
   • Brings you up to date with the latest information in molecular and genetic testing, mechanisms of disease, personalized medicine and its impact on treatment of human diseases, the role of microbiome and metabolome in non-communicable diseases, and much more.
   • Provides access to a wealth of interactive ancillaries online: pathology case studies, videos, self-assessment questions, Targeted Therapy boxes that discuss drug therapy for specific diseases, interactive cases, and more.
   • Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices

The 10th edition of Robbins and Cotran Pathology, with excellent readings and illustrations, offers detailed and up-to-date descriptions of human disease as well as the cellular and molecular environment. This bestseller delivers the latest and most important pathology discoveries in an easy-to-read format, sharing and giving you the best insight into today’s fundamental science and clinical content. Over 1,000 high-quality color photos and illustrations provide fresh information on molecular biology, disease classification, new drugs, chemotherapy and more. This great training package also includes a complete e-book with additional content available on the website. Educational consultation Offers unique, reliable, and easy-to-read coverage, ideal for preparing USMLE or spreadsheets and seminars. New treatment for hepatitis C includes important things to know such as lymphoma, advanced protein response, non-cell death pathways, coronavirus infection, and more, liquid biopsy to diagnose cancer. And regulate iron absorption, blood and blood vessels, thrombosis, thrombocytopenia, inflammation of meiosis, hereditary apparatus for the treatment of cystitis and others.

Use colorful and intuitive layouts to simplify the learning process and quickly introduce the information you need, with teaching features such as general descriptions, basic concepts, measurements, and bold charts introduced at the beginning of. Each chapter shows complex concepts and new and microscopic numbers for a clearer position. Provides the latest information on molecular and genetic testing, disease methods, individual drugs and therapeutic effects of human disease, the role of pathogens and metabolism in non-communicable diseases, and more. Provides access to a wide range of interactive online dietary supplements such as pathology research, videos, self-assessment questions, and targeted treatment plans for chemotherapy, interactions, and more. An extended e-book is included with your modern e-book purchase. You can access all text, images and book links on different devices.

This best-selling text delivers the latest, most essential pathology knowledge in a readable, interesting manner, ensuring optimal understanding of the latest basic science and clinical content.

More than 1,000 high-quality photographs and full-color illustrations highlight new information in molecular biology, disease classifications, new drugs and drug therapies, and much more.

This superb learning package also includes an enhanced eBook with a full complement of ancillary content on Student Consult.

The tenth edition of Pathologic Basis of Disease we look to the future of pathology as a discipline and how this textbook can remain most useful to readers in the twenty-first century. It is obvious that an understanding
of disease mechanisms is based more than ever on a strong foundation of basic science. We have always woven the relevant basic cell and molecular biology into the sections on pathophysiology in various chapters. In the previous edition, we went one step further and introduced a new chapter at the very beginning of the book titled “The Cell as a Unit of Health and Disease.” We are delighted that the
chapter was found useful by many students and faculty. Because progress in basic cell biology is moving at a very brisk pace, the chapter has been updated significantly.
In the preface of the very first edition (1957), Stanley Robbins wrote:

“The pathologist is interested not only in the recognition of structural alterations, but also in their significance, i.e., the effects of these changes on cellular and tissue function and ultimately the effect of these changes on the patient. It is not a discipline isolated from the living patient, but rather a basic approach to a better understanding of disease and therefore a foundation of sound clinical medicine.”
We hope we continue to illustrate the principles of pathology that Dr. Robbins enunciated with such elegance and clarity over half a century ago.
This edition, like all previous ones, has been extensively revised, and some areas have been completely rewritten. A few examples of significant changes are as follows:
• Chapter 2 has been updated to include novel pathways of cell death beyond the long-established pathways of necrosis and apoptosis. Indeed, the distinction between these two is being blurred. Autophagy, which has begun to take center stage in diseases ranging from aging to cancer and neurodegeneration, has been revised, as have the possible molecular mechanisms of aging.

• In Chapter 3, we have married morphology with molecular mechanisms. Thus, different patterns of inflammation can be related to distinct molecular pathways.
• Chapter 5 includes a discussion of gene editing technology and a revised and updated section on molecular diagnosis.
• Chapter 7 has been extensively revised to incorporate new insights into cancer pathogenesis, the interplay between cancer cells and host immunity, and cancer precision diagnostics.
• Chapter 10, covering pediatric diseases, includes discussion of newly approved therapies targeting specific mutated forms of the CFTR transporter.
• Chapter 11, covering vascular diseases, includes discussion of clonal hematopoiesis, a newly emerging risk factor for atherosclerosis and other inflammatory disorders.
• Chapters 18 and 28, covering diseases of the liver and the central nervous system, have a fresh look brought in by new contributors.
• In addition to the revision and reorganization of the text, many new photographs and schematics have been added and a large number of the older “gems” have been enhanced by digital technology.

We made the changes highlighted above while remaining focused on the same longstanding overarching goals, which serve as our guiding principles:
• To integrate into the discussion of pathologic processes and disorders the newest established information available—morphologic as well as molecular.
• To organize information into logical and uniform presentations,facilitating readability, comprehension, and learning.
• To maintain the book at a reasonable size and yet provide adequate discussion of significant lesions, processes, and disorders. Indeed, despite the addition of new information, we are happy to state that the overall length of the book
is unchanged. One of our most challenging tasks is to decide what to eliminate to make room for key new findings.
• To place great emphasis on clarity of writing and proper use of language in the recognition that struggling to comprehend is time-consuming and wearisome and gets in the way of the learning process.
• To make this text useful to students throughout all of their years in medical school and into their residencies—but, at the same time, to provide sufficient detail and depth to meet the needs of more advanced readers.

We have repeatedly been told by readers that up-to-datedness is a special feature that makes this book very valuable. We have strived to remain current by providing new information from the recent literature, up to the current year, and by adding coverage of the COVID-19 epidemic.

All three of us have reviewed, critiqued, and edited each chapter to ensure the uniformity of style and flow that have been the hallmarks of the book. Together, we hope that we have succeeded in equipping the readers with the scientific

basis for the practice of medicine and in whetting their appetite for learning beyond what can be offered in any textbook.