Authors Page: v
Preface Page: vii
Acknowledgments Page: ix
How to Use This Book Page: xi
PART I
BASIC BACTERIOLOGY Page: 1
1. Bacteria Compared With Other Microorganisms Page: 1
2. Structure of Bacterial Cells Page: 4
3. Growth Page: 15
4. Genetics Page: 18
5. Classification of Medically Important Bacteria Page: 24
6. The Human Microbiome Page: 26
7. Pathogenesis Page: 31
8. Host Defenses Page: 51
9. Laboratory Diagnosis Page: 59
10. Antibacterial Drugs: Mechanism of Action Page: 68
11. Antibacterial Drugs: Resistance Page: 85
12. Bacterial Vaccines Page: 94
13. Sterilization & Disinfection Page: 99
PART II CLINICAL BACTERIOLOGY Page: 105
14. Overview of the Major Pathogens & Introduction to Anaerobic Bacteria Page: 105
15. Gram-Positive Cocci Page: 108
16. Gram-Negative Cocci Page: 127
17. Gram-Positive Rods Page: 134
18. Gram-Negative Rods Related to the Enteric Tract Page: 146
19. Gram-Negative Rods Related to the Respiratory Tract Page: 167
20. Gram-Negative Rods Related to Animal Sources (Zoonotic Organisms) Page: 172
21. Mycobacteria Page: 179
22. Actinomycetes Page: 190
23. Mycoplasmas Page: 193
24. Spirochetes Page: 195
25. Chlamydiae Page: 204
26. Rickettsiae Page: 208
27. Minor Bacterial Pathogens Page: 213 PART III BASIC VIROLOGY Page: 219
28. Structure Page: 220
29. Replication Page: 226
30. Genetics & Gene Therapy Page: 239
31. Classification of Medically Important Viruses Page: 243
32. Pathogenesis Page: 248
33. Host Defenses Page: 256
34. Laboratory Diagnosis Page: 262
35. Antiviral Drugs Page: 266
36. Viral Vaccines Page: 277
PART IV CLINICAL VIROLOGY Page: 283
37. Herpesviruses, Poxviruses, & Human Papilloma Virus Page: 285
38. Respiratory Viruses Page: 305
39. Important Childhood Viruses Page: 318
40. Viruses That Infect the Enteric Tract Page: 327
41. Hepatitis Viruses Page: 335
42. Arboviruses, Rabies Virus, & Ebola Virus Page: 348
43. Tumor Viruses Page: 359
44. Slow Viruses & Prions Page: 371
45. Human Immunodeficiency Virus Page: 377
46. Minor Viral Pathogens Page: 390
PART V MYCOLOGY Page: 395
47. Basic Mycology Page: 395
48. Cutaneous & Subcutaneous Mycoses Page: 403
49. Systemic Mycoses Page: 407
50. Opportunistic Mycoses Page: 414
PART VI PARASITOLOGY Page: 423
51. Intestinal & Urogenital—Protozoa Page: 424
52. Blood & Tissue Protozoa Page: 433
53. Minor Protozoan Pathogens Page: 450
54. Cestodes Page: 453
55. Trematodes Page: 463
56. Nematodes Page: 470
PART VII IMMUNOLOGY Page: 489
57. Overview of Immunity Page: 489
58. Innate Immunity Page: 495
59. Adaptive Immunity: Lymphocyte Antigen Receptors Page: 507
60. Adaptive Immunity: T-Cell–Mediated Immunity Page: 518
61. Adaptive Immunity: B Cells & Antibodies Page: 532
62. Major Histocompatibility Complex & Transplantation Page: 544
63. Complement Page: 552
64. Antigen–Antibody Reactions in the Laboratory Page: 556
65. Hypersensitivity (Allergy) Page: 567
66. Tolerance & Autoimmune Disease Page: 578
67. Tumor Immunity Page: 588
68. Immunodeficiency Page: 591
PART VIII ECTOPARASITES Page: 599
69. Ectoparasites That Cause Human Disease Page: 599
PART IX INFECTIOUS DISEASES Page: 607
70. Bone & Joint Infections Page: 607 .
71. Cardiac Infections Page: 612
72. Central Nervous System Infections Page: 618
73. Gastrointestinal Tract Infections Page: 627
74. Pelvic Infections Page: 635
75. Upper Respiratory Tract Infections Page: 643
76. Lower Respiratory Tract Infections Page: 649
77. Infections of the Skin & Skin Structures Page: 655
78. Urinary Tract Infections Page: 662
79. Sepsis & Septic Shock Page: 666
80. Eye Infections Page: 670
PART X
BRIEF SUMMARIES OF MEDICALLY IMPORTANT ORGANISMS Page: 677
PART XI CLINICAL CASES Page: 717
PART XII PEARLS FOR THE USMLE Page: 727
PART XIII USMLE (NATIONAL BOARD) PRACTICE QUESTIONS Page: 735
PART XIV USMLE (NATIONAL BOARD) PRACTICE EXAMINATION Page: 777 INDEX Page: 787